Abath F G, Montenegro S M, Gomes Y M
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Cidade Universitaria, Recife-PE, Brazil.
Acta Trop. 1998 Nov 30;71(3):237-54. doi: 10.1016/s0001-706x(98)00066-7.
There are no vaccines currently available to control the major human parasitic diseases, although there is evidence of acquired immunity and resistance to reinfection in most of the parasitic infections. The present manuscript concentrates on the vaccines for parasitic diseases that are in the most advanced stages of development: malaria, leishmaniasis and schistosomiasis. Vaccines for malaria and leishmaniasis have been taken to clinical trials while vaccines for schistosomiasis are being considered for Phase I (assessment of safety and immune responsiveness in volunteers). We have attempted to give a factual account of the present status of knowledge of vaccines against human parasitic diseases, emphasizing both the successes and setbacks. We do not intend to cover the enormous literature in the field but have concentrated on the most promising antigenic preparations. Finally, some new approaches for the development of vaccines are discussed including nucleic acid vaccines and the use of cytokines as adjuvants.
目前尚无用于控制主要人类寄生虫病的疫苗，尽管在大多数寄生虫感染中都有获得性免疫和对再感染产生抵抗力的证据。本手稿主要关注处于最先进研发阶段的寄生虫病疫苗：疟疾、利什曼病和血吸虫病。疟疾和利什曼病疫苗已进入临床试验阶段，而血吸虫病疫苗正考虑进入I期试验（评估志愿者的安全性和免疫反应性）。我们试图对人类寄生虫病疫苗的现有知识状况进行实事求是的描述，既强调成功之处，也提及挫折。我们并不打算涵盖该领域的大量文献，而是专注于最有前景的抗原制剂。最后，讨论了疫苗研发的一些新方法，包括核酸疫苗以及使用细胞因子作为佐剂。
