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用于寄生虫感染的DNA疫苗。

DNA vaccines for parasitic infections.

作者信息

Kalinna B H

机构信息

Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia.

出版信息

Immunol Cell Biol. 1997 Aug;75(4):370-5. doi: 10.1038/icb.1997.58.

DOI:10.1038/icb.1997.58
PMID:9315480
Abstract

There has been a tremendous explosion in the area of DNA vaccine research over the last 4 years, particularly in relation to antiviral vaccines. This report discusses the development and application of this new technology with regard to parasitic infections. Progress has been made towards the development of a vaccine against malaria, cryptosporidiosis, leishmaniasis, toxoplasmosis and schistosomiasis. In the future, nucleic acid vaccines will be a useful tool to help control these and other parasitic infections.

摘要

在过去4年里,DNA疫苗研究领域出现了巨大的突破,尤其是在抗病毒疫苗方面。本报告讨论了这项新技术在寄生虫感染方面的开发和应用。在开发抗疟疾、隐孢子虫病、利什曼病、弓形虫病和血吸虫病疫苗方面已取得进展。未来,核酸疫苗将成为帮助控制这些及其他寄生虫感染的有用工具。

相似文献

1
DNA vaccines for parasitic infections.用于寄生虫感染的DNA疫苗。
Immunol Cell Biol. 1997 Aug;75(4):370-5. doi: 10.1038/icb.1997.58.
2
Immune response to parasitic infections--an introduction.对寄生虫感染的免疫反应——引言
Curr Drug Targets Immune Endocr Metabol Disord. 2002 Oct;2(3):193-9. doi: 10.2174/1568008023340569.
3
Parasite Carbohydrate Vaccines.寄生虫碳水化合物疫苗
Front Cell Infect Microbiol. 2017 Jun 12;7:248. doi: 10.3389/fcimb.2017.00248. eCollection 2017.
4
Antigenic glycans in parasitic infections: implications for vaccines and diagnostics.寄生虫感染中的抗原聚糖:对疫苗和诊断的影响。
Arch Biochem Biophys. 2004 Jun 15;426(2):182-200. doi: 10.1016/j.abb.2004.04.004.
5
c-DNA vaccination against parasitic infections: advantages and disadvantages.针对寄生虫感染的cDNA疫苗接种:优点与缺点。
Vet Parasitol. 2001 Sep 12;100(1-2):3-12. doi: 10.1016/s0304-4017(01)00478-2.
6
Protection tests against parasitic diseases.针对寄生虫病的防护测试。
Comp Immunol Microbiol Infect Dis. 1986;9(2-3):217-23. doi: 10.1016/0147-9571(86)90014-7.
7
Vaccines against human parasitic diseases: an overview.抗人类寄生虫病疫苗:概述
Acta Trop. 1998 Nov 30;71(3):237-54. doi: 10.1016/s0001-706x(98)00066-7.
8
[The new generations of vaccines against parasites].[新一代抗寄生虫疫苗]
Wiad Parazytol. 2000;46(1):21-7.
9
[The vaccines against toxoplasmosis--current status of the studies].[抗弓形虫病疫苗——研究现状]
Wiad Parazytol. 2007;53(3):195-201.
10
Immunological aspects of some parasitic infections.某些寄生虫感染的免疫学方面
Tijdschr Diergeneeskd. 1980 Jul 15;105(14):suppl 3:166-75.

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Malaria vaccines: looking back and lessons learnt.疟疾疫苗:回顾与经验教训
Asian Pac J Trop Biomed. 2011 Jan;1(1):74-8. doi: 10.1016/S2221-1691(11)60072-5.
4
Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB/c mice.评价编码弓形虫表面抗原 1(SAG1)和 14-3-3 蛋白的 DNA 疫苗在 BALB/c 小鼠中诱导的保护性免疫应答。
Parasit Vectors. 2012 Nov 26;5:273. doi: 10.1186/1756-3305-5-273.
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Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2.通过编码核衣壳蛋白和白细胞介素-2的双顺反子质粒增强传染性支气管炎病毒DNA疫苗的免疫原性。
J Virol Methods. 2008 Apr;149(1):42-8. doi: 10.1016/j.jviromet.2008.01.017. Epub 2008 Mar 7.
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Brugia malayi: comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model.马来布鲁线虫:在沙鼠模型中比较Bm-alt-2 DNA、重组Bm-ALT-2蛋白及初免-加强疫苗方案诱导的保护性免疫反应
Exp Parasitol. 2007 Aug;116(4):483-91. doi: 10.1016/j.exppara.2007.02.017. Epub 2007 Mar 6.
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Evaluation of the persistence and gene expression of an anti-Chlamydophila psittaci DNA vaccine in turkey muscle.火鸡肌肉中抗鹦鹉热嗜衣原体DNA疫苗的持久性和基因表达评估
BMC Vet Res. 2006 Jun 9;2:18. doi: 10.1186/1746-6148-2-18.
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Infect Immun. 2005 Nov;73(11):7089-98. doi: 10.1128/IAI.73.11.7089-7098.2005.