Preston E, Jönsson A C, McManus C D, Conlon J M, Courtice G P
School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.
Regul Pept. 1998 Nov 30;78(1-3):57-67. doi: 10.1016/s0167-0115(98)00116-5.
The vascular responses to neuropeptide Y (NPY) and peptide YY (PYY) were tested in several species of elasmobranchs to assess whether changes in sequence in these neuropeptides from elasmobranchs to mammals are associated with different physiological responses. NPY-like immunoreactivity was detected in the gut and in nerve fibres surrounding some, but not all, blood vessels of six species. Intravenous injection of dogfish, frog and human NPY in anaesthetised fish caused similar vasopressor effects in the three species tested, except human NPY which lowered blood pressure in one of the three. Dogfish NPY and PYY were equipotent pressor agents in two species, but PYY was significantly more potent than NPY in one species. NPY and PYY both contracted isolated gut arteries from three species, but had no effect on isolated efferent arteries tested. In conclusion, differential vascular responses in elasmobranchs are not associated with changes in NPY sequence across vertebrates, but may be with changes in PYY in some species.
在几种软骨鱼类中测试了对神经肽Y（NPY）和肽YY（PYY）的血管反应，以评估从软骨鱼类到哺乳动物这些神经肽的序列变化是否与不同的生理反应相关。在六种物种的肠道以及部分（但不是全部）血管周围的神经纤维中检测到了NPY样免疫反应性。在麻醉的鱼类中静脉注射狗鱼、青蛙和人类的NPY，在测试的三个物种中引起了类似的升压作用，但人类NPY在三个物种中的一个中降低了血压。狗鱼NPY和PYY在两个物种中是等效的升压剂，但在一个物种中PYY比NPY的效力明显更强。NPY和PYY都使来自三个物种的离体肠动脉收缩，但对测试的离体传出动脉没有影响。总之，软骨鱼类中的不同血管反应与整个脊椎动物中NPY序列的变化无关，但在某些物种中可能与PYY的变化有关。
