肽类物质神经肽Y和肽YY对犬离体血液灌注脾脏的血管和平滑肌包膜的作用。
The actions of the peptides, neuropeptide Y and peptide YY, on the vascular and capsular smooth muscle of the isolated, blood-perfused spleen of the dog.
作者信息
Corder R, Lowry P J, Withrington P G
出版信息
Br J Pharmacol. 1987 Apr;90(4):785-90. doi: 10.1111/j.1476-5381.1987.tb11232.x.
Abstract
The two peptides, neuropeptide Y (NPY) and peptide YY (PYY) were compared for potency on the vascular and extravascular smooth muscle of the isolated, blood-perfused spleen of the dog. The only vascular response to both NPY and PYY was vasoconstriction; the maximum effect was to arrest splenic arterial blood flow completely. On a molar basis both NPY and PYY were significantly more potent (P less than 0.01) as splenic arterial vasoconstrictors than the transmitter noradrenaline (NA). PYY was approximately 7 times more potent as a vasoconstrictor than NPY. In contrast to their potency on the vascular smooth muscle, NPY and PYY were significantly (P less than 0.01) less potent than NA in causing contraction of the splenic capsule. The two peptides were equipotent in eliciting this contraction.
摘要
对两种肽，即神经肽Y（NPY）和肽YY（PYY）在犬离体、血液灌注脾脏的血管和血管外平滑肌上的效力进行了比较。NPY和PYY唯一的血管反应均为血管收缩；最大效应是使脾动脉血流完全停止。以摩尔计，NPY和PYY作为脾动脉血管收缩剂的效力均显著高于递质去甲肾上腺素（NA）（P<0.01）。PYY作为血管收缩剂的效力约为NPY的7倍。与它们对血管平滑肌的效力相反，NPY和PYY在引起脾包膜收缩方面的效力显著低于NA（P<0.01）。这两种肽在引发这种收缩方面效力相当。
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