Kawamoto A, Kawata H, Akai Y, Katsuyama Y, Takase E, Sasaki Y, Tsujimura S, Sakaguchi Y, Iwano M, Fujimoto S, Hashimoto T, Dohi K
First Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
Int J Cardiol. 1998 Nov 30;67(1):47-54. doi: 10.1016/s0167-5273(98)00251-4.
We examined serial changes in serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) measured by ELISAs in 45 patients with acute myocardial infarction (AMI) who received heparin intravenously for 3 to 5 days after the onset and in 30 control subjects with an old myocardial infarction. To evaluate the effect of heparin on these serum levels, heparin was administered intravenously in 10 patients with AMI on day 21. Blood samples were obtained from all AMI patients on days 1, 2, 3, 7, 14, 21, and 28 and from 10 AMI patients before and 1 h after heparin administration. Serum VEGF level was significantly reduced after heparin administration (P<0.001). Serum samples from day 1 to 3 were therefore excluded from the subsequent analysis. Serum VEGF level in AMI patients was significantly higher on day 7 than in the control subjects (P<0.0001), and then decreased over time (P<0.0001). The serum VEGF level on day 7 was independently associated with the peak serum CK level (P<0.05). The serum bFGF level did not differ significantly between the AMI patients and the control subjects. In conclusion, the serum VEGF level may be selectively elevated during the healing process after AMI.
我们检测了45例急性心肌梗死（AMI）患者和30例陈旧性心肌梗死对照者血清中血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）水平的系列变化，这些AMI患者在发病后静脉注射肝素3至5天。为评估肝素对这些血清水平的影响，在第21天对10例AMI患者静脉注射肝素。在第1、2、3、7、14、21和28天从所有AMI患者采集血样，并在肝素给药前和给药后1小时从10例AMI患者采集血样。肝素给药后血清VEGF水平显著降低（P<0.001）。因此，后续分析排除第1至3天的血清样本。AMI患者第7天的血清VEGF水平显著高于对照者（P<0.0001），随后随时间下降（P<0.0001）。第7天的血清VEGF水平与血清CK峰值水平独立相关（P<0.05）。AMI患者和对照者之间的血清bFGF水平无显著差异。总之，AMI后愈合过程中血清VEGF水平可能会选择性升高。
