Sun Xiaomeng, Zhang Heng, Liu Jia, Wang Guang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, P. R. China.
J Int Med Res. 2019 Nov;47(11):5584-5592. doi: 10.1177/0300060519872033. Epub 2019 Sep 23.
This study was performed to investigate the serum vascular endothelial growth factor (VEGF) levels in Chinese patients with impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes mellitus (T2DM).
A total of 189 subjects (41 controls, 40 patients with IGT, and 108 patients with newly diagnosed T2DM) were recruited. Serum VEGF levels were determined by ELISA; other metabolic parameters were assessed by standard laboratory methods.
There were significant differences in serum VEGF levels among the T2DM, IGT, and control groups (T2DM vs. controls: 72.00 [45.40, 98.35] pg/mL vs. 53.10 [36.30, 116.25] pg/mL; IGT vs. controls: 78.17 [55.52, 137.25] pg/mL vs. 53.10 [36.30, 116.25] pg/mL). Moreover, serum VEGF levels were positively associated with the homeostasis model assessment for insulin resistance (HOMA-IR) value. Multiple linear regression analysis indicated that the HOMA-IR value was an independent risk factor for elevated serum VEGF level.
Both IGT and T2DM patients exhibited increased serum VEGF levels, compared with controls; increased serum VEGF level was positively associated with the HOMA-IR value. Therefore, the increased serum VEGF level might partially result from increased insulin resistance in these patients.
本研究旨在调查糖耐量受损（IGT）的中国患者和新诊断的2型糖尿病（T2DM）患者的血清血管内皮生长因子（VEGF）水平。
共招募了189名受试者（41名对照者、40名IGT患者和108名新诊断的T2DM患者）。通过酶联免疫吸附测定法（ELISA）测定血清VEGF水平；其他代谢参数通过标准实验室方法进行评估。
T2DM组、IGT组和对照组之间的血清VEGF水平存在显著差异（T2DM组与对照组：72.00 [45.40, 98.35] pg/mL对53.10 [36.30, 116.25] pg/mL；IGT组与对照组：78.17 [55.52, 137.25] pg/mL对53.10 [36.30, 116.25] pg/mL）。此外，血清VEGF水平与胰岛素抵抗稳态模型评估（HOMA-IR）值呈正相关。多元线性回归分析表明，HOMA-IR值是血清VEGF水平升高的独立危险因素。
与对照组相比，IGT和T2DM患者的血清VEGF水平均升高；血清VEGF水平升高与HOMA-IR值呈正相关。因此，这些患者血清VEGF水平升高可能部分归因于胰岛素抵抗增加。
