Ronen G M, Penney S, Andrews W
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
J Pediatr. 1999 Jan;134(1):71-5. doi: 10.1016/s0022-3476(99)70374-4.
To study the incidence, clinical features, etiologic distribution, and day of seizure onset by etiology in neonates with seizures.
Prospective, population-based study involving all the obstetric and neonatal units across the province of Newfoundland, Canada. All units were given educational sessions on neonatal seizure symptomatology.
Detailed questionnaires were prospectively collected for all infants with probable neonatal seizures for a period of 5 years.
The incidence rate was 2. 6 per 1000 live births, 2.00 for term neonates, 11.1 for preterm neonates, and 13.5 for infants weighing <2500 g at birth. Seizures lasting 30 minutes or longer were present in 5%, and the neonatal death rate among infants with seizures was 9%. Hypoxic-ischemic encephalopathy was the presumed cause in 40%, infections in 20%, and metabolic abnormalities in 19%.
Clinical neonatal seizures occur 6 times more often in preterm infants than in term infants. Hypoxic-ischemic encephalopathy continues to be a major marker of the likelihood of seizures.
研究新生儿惊厥的发病率、临床特征、病因分布以及按病因划分的惊厥发作日。
一项基于人群的前瞻性研究，涉及加拿大纽芬兰省所有产科和新生儿科单位。所有单位都接受了关于新生儿惊厥症状学的培训课程。
对所有可能患有新生儿惊厥的婴儿进行了为期5年的详细问卷前瞻性收集。
发病率为每1000例活产儿中有2.6例，足月儿为2.00例，早产儿为11.1例，出生体重<2500g的婴儿为13.5例。持续30分钟或更长时间的惊厥占5%，惊厥婴儿的新生儿死亡率为9%。40%的病例推测病因是缺氧缺血性脑病，20%是感染，19%是代谢异常。
早产儿临床新生儿惊厥的发生率比足月儿高6倍。缺氧缺血性脑病仍然是惊厥可能性的主要标志。
