脑脊液乳酸在先天性乳酸性酸中毒评估中的重要性。

The importance of cerebrospinal fluid lactate in the evaluation of congenital lactic acidosis.

作者信息

Stacpoole P W, Bunch S T, Neiberger R E, Perkins L A, Quisling R, Hutson A D, Greer M

机构信息

Departments of Medicine (Division of Endocrinology and Metabolism), University of Florida, College of Medicine, Gainesville, USA.

出版信息

J Pediatr. 1999 Jan;134(1):99-102. doi: 10.1016/s0022-3476(99)70379-3.

DOI:10.1016/s0022-3476(99)70379-3

PMID:9880457

Abstract

In 27 of 28 children with congenital lactic acidosis, cerebrospinal fluid lactate was higher than venous blood lactate. The mean +/- SEM difference between these variables was 2.4 +/- 0.3 mmol/L (P =.0001). Girls or patients with pyruvate dehydrogenase deficiency had higher cerebrospinal fluid lactate concentrations than boys or patients with respiratory chain defects or mitochondrial DNA mutations.

摘要

在28例先天性乳酸性酸中毒患儿中，27例患儿的脑脊液乳酸水平高于静脉血乳酸水平。这些变量之间的平均差异±标准误为2.4±0.3 mmol/L（P = 0.0001）。女孩或丙酮酸脱氢酶缺乏症患者的脑脊液乳酸浓度高于男孩或呼吸链缺陷或线粒体DNA突变患者。