Bhattacharya S K, Reddy P K, Ghosal S, Singh A K, Sharma P V
J Pharm Sci. 1976 Oct;65(10):1547-9. doi: 10.1002/jps.2600651037.
CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that swertiamarin and mangiferin antagonize each other in vivo and thereby reverse their CNS effects.
对獐牙菜苦苷（一种来自印度獐牙菜的裂环烯醚萜苷）的中枢神经系统活性进行了评估。一个明显的异常现象得到了解决，该异常与意外发现有关，即印度獐牙菜的乙醇提取物（不包括芒果苷）能显著逆转芒果苷对白化病小鼠和大鼠的中枢神经系统刺激作用。结果表明，獐牙菜苦苷和芒果苷在体内相互拮抗，从而逆转它们对中枢神经系统的作用。
