将Notch信号通路与胸腺细胞成熟相关联。
Correlating notch signaling with thymocyte maturation.
作者信息
Deftos M L, He Y W, Ojala E W, Bevan M J
机构信息
Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA.
出版信息
Immunity. 1998 Dec;9(6):777-86. doi: 10.1016/s1074-7613(00)80643-3.
Abstract
The Notch receptor and its ligands are involved in many developmental processes. They are highly expressed in the thymus and have been implicated in the CD4 versus CD8 lineage decision. We identified the constitutively active intracellular fragment of murine Notch-1 as capable of rendering thymomas resistant to glucocorticoid-induced apoptosis. This effect was confirmed in other T cell lines and in CD4+ CD8+ DP thymocytes. Activation of the Notch signaling pathway also upregulated a number of other markers that, like steroid resistance, correlate with DP maturation into both the CD4 and CD8 lineages. These results suggest that Notch signaling is critically involved in the maturation of DP thymocytes into both CD4+ and CD8+ SP thymocytes.
摘要
Notch受体及其配体参与许多发育过程。它们在胸腺中高度表达，并与CD4与CD8谱系决定有关。我们发现小鼠Notch-1的组成型活性细胞内片段能够使胸腺瘤对糖皮质激素诱导的凋亡产生抗性。这种效应在其他T细胞系和CD4+CD8+双阳性（DP）胸腺细胞中得到证实。Notch信号通路的激活还上调了许多其他标志物，这些标志物与类固醇抗性一样，与DP细胞成熟为CD4和CD8谱系相关。这些结果表明，Notch信号通路在DP胸腺细胞成熟为CD4+和CD8+单阳性（SP）胸腺细胞的过程中起关键作用。
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