Noguchi S, Nishitani H
Neurology. 1976 Nov;26(11):1075-80. doi: 10.1212/wnl.26.11.1075.
A case of myasthenia gravis was associated with thymoma and pemphigus vulgaris. The bullous lesions developed after partial thymomectomy, cobalt (60Co) irradiation, and 3 days' extensive sunbathing, although a retrospective study of the patient's sera by quantitative indirect immunofluorescence method indicated that antiepithelial antibody already was positive before the clinical appearance of pemphigus vulgaris. Serial observation of the patient's clinical course and titrations of antiepithelial, antimuscle, and antithymus antibodies suggested a reverse relationship between the severity of myasthenia gravis and titers of antimuscle and anitithymus antibodies, and a parallel relationship between pemphigus vulgaris and antiepithelial antibody. Review of the literature suggests a close relationship between pemphigus vulgaris and myasthenia gravis and thymoma, particularly thymoma injured by medical procedures.
1例重症肌无力合并胸腺瘤及寻常型天疱疮。大疱性皮损在部分胸腺切除、钴（60Co）照射及3天大量日光浴后出现，尽管通过定量间接免疫荧光法对患者血清进行回顾性研究表明，抗上皮抗体在寻常型天疱疮临床表现出现之前就已呈阳性。对患者临床病程的连续观察以及抗上皮、抗肌肉和抗胸腺抗体的滴定结果提示，重症肌无力的严重程度与抗肌肉和抗胸腺抗体滴度呈反向关系，而寻常型天疱疮与抗上皮抗体呈平行关系。文献回顾表明寻常型天疱疮与重症肌无力及胸腺瘤之间关系密切，尤其是受医疗操作损伤的胸腺瘤。
