Peterson A, Brant D, Kirsh M M
Surgery. 1978 Aug;84(2):216-23.
The effects of an intravenous infusion of nitroglycerin on cardiac index and peripheral vascular resistance during infrarenal aortic cross-clamping were determined in normal animals and in animals subjected to low cardiac output state. Both groups of untreated animals demonstrated progressive fall in cardiac index with a rise in total peripheral resistance during infrarenal aortic cross-clamping. The infusion of nitroglycerin during the period of aortic cross-clamping prevented the increase in total peripheral resistance and therefore prevented the progressive fall in cardiac index that occurred in untreated animals. In the animals with depressed myocardial function, the infusion of nitroglycerin produced a 44% increase in cardiac index during aortic cross-clamping. The results of this study showed that the infusion of nitroglycerin during abdominal aortic cross-clamping can prevent adverse cardiovascular sequelae from occurring and should be used in patients undergoing abdominal aortic resection, especially those with impairment of left ventricular function.
在正常动物和处于低心输出量状态的动物中，测定了肾下腹主动脉交叉钳夹期间静脉输注硝酸甘油对心脏指数和外周血管阻力的影响。两组未经治疗的动物在肾下腹主动脉交叉钳夹期间均表现出心脏指数逐渐下降，总外周阻力升高。在主动脉交叉钳夹期间输注硝酸甘油可防止总外周阻力增加，从而防止未治疗动物出现的心脏指数逐渐下降。在心肌功能受损的动物中，主动脉交叉钳夹期间输注硝酸甘油使心脏指数增加了44%。本研究结果表明，腹主动脉交叉钳夹期间输注硝酸甘油可预防不良心血管后遗症的发生，应用于接受腹主动脉切除术的患者，尤其是左心室功能受损的患者。
