Johansson J, Santala M, Kauppila A
Department of Obstetrics and Gynaecology, University of Oulu, Finland.
Hum Reprod. 1998 Dec;13(12):3503-4. doi: 10.1093/humrep/13.12.3503.
Serum CA 125 concentration is seldom >100 IU/ml in endometriosis. We report a patient with ruptured endometrioma presenting with a very high CA 125 concentration, 9300 IU/ml. Elimination of endometriosis was followed by a sharp decrease in serum CA 125. We conclude that some of the CA 125 molecules from the ruptured endometriotic cyst may be transferred through the peritoneum, thereby increasing serum CA 125 concentration. The associated inflammatory reaction of the mesothelial cells of the peritoneum was probably the most important contributor to this phenomenon, as mesothelial cells are an important source of CA 125.
在子宫内膜异位症中，血清CA 125浓度很少超过100 IU/ml。我们报告了一名子宫内膜瘤破裂的患者，其血清CA 125浓度非常高，达9300 IU/ml。子宫内膜异位症消除后，血清CA 125急剧下降。我们得出结论，破裂的子宫内膜异位囊肿中的一些CA 125分子可能通过腹膜转移，从而增加血清CA 125浓度。腹膜间皮细胞的相关炎症反应可能是这一现象的最重要促成因素，因为间皮细胞是CA 125的重要来源。
