Gorenstein A, Neel H B, Sanderson D R
Ann Otol Rhinol Laryngol. 1976 Sep-Oct;85(5 Pt.1):670-8. doi: 10.1177/000348947608500518.
Although resection is the only treatment proven effective for localized malignant tumors in the tracheobronchial tree, alternative methods for cure or control of unresectable or recurrent tumor should be explored. In 24 dogs, cryonecrosis of sizable portions of carina, main stem bronchi, first division bronchi, and lung parenchyma was well tolerated, and the necrosis was localized, reproducible, and followed by prompt healing of frozen tissue. The gross architecture of the bronchi was not permanently altered, and no strictures formed. Six patients with endobronchial tumors were treated transbronchoscopically with cryosurgery. All patients tolerated the procedures well, and there were no complications. Palliation was achieved in five of the six patients.
尽管手术切除是已被证实对气管支气管树局限性恶性肿瘤有效的唯一治疗方法，但仍应探索治疗无法切除或复发性肿瘤的其他治愈或控制方法。在24只犬中，隆突、主支气管、一级分支支气管和肺实质相当大一部分的冷冻坏死耐受性良好，坏死局限、可重复，随后冷冻组织迅速愈合。支气管的大体结构未发生永久性改变，也未形成狭窄。6例支气管内肿瘤患者接受了经支气管镜冷冻手术治疗。所有患者对手术耐受性良好，且无并发症。6例患者中有5例病情得到缓解。
