Geerling G, Koop N, Brinkmann R, Tüngler A, Wirbelauer C, Birngruber R, Laqua H
Department of Ophthalmology, Medical University Lübeck, Germany.
J Cataract Refract Surg. 1999 Jan;25(1):32-40. doi: 10.1016/s0886-3350(99)80008-x.
To evaluate the safety and stability of laser thermokeratoplasty (LTK) with a continuous-wave diode laser in blind human eyes and to optimize parameters for a study in sighted eyes.
Department of Ophthalmology, Medical University Lübeck, Germany.
A continuous-wave diode laser was set to emit radiation with a wavelength of 1.854 microns (Group 1, n = 4) or 1.870 microns (Group 2, n = 4) and 100 to 150 mW power for 10 seconds. A focusing handpiece was coupled with an application mask and fixed by partial vacuum to the conjunctiva or cornea. The radiation was focused into the corneal stroma between 400 and 600 microns in Group 1 and set to 1000 microns in Group 2. Eight (Group 1, single ring) or 16 (Group 2, double ring) coagulations were applied.
The refractive change increased with higher laser power and smaller ring diameters. Two rings of coagulations provided higher and more stable refractive changes of up to 5.66 diopters (D) than a single ring. The refractive effect stabilized between 3 and 6 months postoperatively. At 1 year, mean refractive change was +0.99 D +/- 0.39 (SD) in Group 1 and +2.32 +/- 2.24 D in Group 2. Extensive endothelial damage occurred in Group 1 but was minimal in Group 2.
Diode LTK was used to treat hyperopia safely and effectively. Regression occurred mainly in the first 3 postoperative months. With a wavelength of 1.870 microns, corneal endothelial damage was limited.
评估连续波二极管激光热角膜成形术（LTK）在盲人眼中的安全性和稳定性，并为有视力眼睛的研究优化参数。
德国吕贝克医科大学眼科。
将连续波二极管激光设置为发射波长为1.854微米的辐射（第1组，n = 4）或1.870微米的辐射（第2组，n = 4），功率为100至150毫瓦，持续10秒。一个聚焦手持件与一个应用面罩相连，并通过部分真空固定在结膜或角膜上。第1组的辐射聚焦到角膜基质中400至600微米之间，第2组设置为1000微米。进行了8次（第1组，单环）或16次（第2组，双环）凝固。
屈光变化随激光功率的增加和环直径的减小而增加。与单环相比，双环凝固提供了更高且更稳定的屈光变化，高达5.66屈光度（D）。屈光效果在术后3至6个月稳定下来。1年后，第1组的平均屈光变化为+0.99 D±0.39（标准差），第2组为+2.32±2.24 D。第1组发生了广泛的内皮损伤，但第2组最小。
二极管LTK可安全有效地治疗远视。屈光回退主要发生在术后的前3个月。波长为1.870微米时，角膜内皮损伤有限。
