Department of Ophthalmology, University Hospital, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Medical Laser Center Luebeck, Peter-Monnik-Weg 4, 23562 Luebeck, Germany.
Int J Mol Sci. 2023 Mar 1;24(5):4757. doi: 10.3390/ijms24054757.
Preliminary clinical work indicates that increasing eyelid tension improves the function of the meibomian glands. The aim of this study was to optimize laser parameters for a minimally invasive laser treatment to increase eyelid tension by coagulation of the lateral tarsal plate and canthus.
Experiments were performed on a total of 24 porcine lower lids post mortem, with six lids in each group. Three groups were irradiated with an infrared B radiation laser. Laser-induced lower eyelid shortening was measured and the increase in eyelid tension was assessed with a force sensor. A histology was performed to evaluate coagulation size and laser-induced tissue damage.
In all three groups, a significant shortening of the eyelids after irradiation was noticed ( < 0.0001). The strongest effect was seen with 1940 nm/1 W/5 s, showing -15.1 ± 3.7% and -2.5 ± 0.6 mm lid shortening. The largest significant increase in eyelid tension was seen after placing the third coagulation.
Laser coagulation leads to lower eyelid shortening and an increase in lower eyelid tension. The strongest effect with the least tissue damage was shown for laser parameters of 1470 nm/2.5 W/2 s. In vivo studies of this effect have to confirm the efficacy of this concept prior to clinical application.
初步临床工作表明，增加眼睑张力可改善睑板腺的功能。本研究旨在通过对外侧睑板和眼角的凝固来优化激光参数，以实现微创激光治疗来增加眼睑张力。
本研究共对 24 只猪的下眼睑进行了死后实验，每组 6 只。三组用红外 B 辐射激光照射。测量激光诱导的下眼睑缩短，并使用力传感器评估眼睑张力的增加。进行组织学检查以评估凝固大小和激光诱导的组织损伤。
三组照射后眼睑均明显缩短（<0.0001）。1940nm/1W/5s 组的效果最强，眼睑缩短-15.1±3.7%和-2.5±0.6mm。放置第三次凝固时，眼睑张力的增加最大。
激光凝固可导致下眼睑缩短和下眼睑张力增加。1470nm/2.5W/2s 的激光参数显示出最强的效果和最小的组织损伤。在临床应用之前，必须通过该效果的体内研究来证实这一概念的有效性。
