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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Boucher M, Chassaing C, Chapuy E, Lorente P

Department of Physiology, Faculty of Pharmacy, Clermont-Ferrand, France.

Gen Pharmacol. 1999 Jan;32(1):47-50. doi: 10.1016/s0306-3623(98)00056-1.

This work determines the effects of quinidine, verapamil, nifedipine and ouabain on the hysteresis of the atrial effective refractory period (AERP) in the conscious dog. 2. AERP was always longer in the increasing phase than in the decreasing phase of the extrastimulus method, thus demonstrating the existence of AERP hysteresis. Calculated as the difference between the two values, hysteresis was between 8+/-0.8 and 11+/-1.0 msec. 3. Quinidine increased hysteresis from 9+/-0.7 to 13+/-0.7 msec, whereas verapamil decreased it from 10+/-0.9 to 5+/-0.5 msec and nifedipine did not affect it. Ouabain also lengthened hysteresis from 8+/-0.8 to 11+/-1.2 msec. 4. Thus, these results confirm the existence of a hysteresis phenomenon in the AERP in the conscious dog and are evidence that the fast sodium and slow calcium specific membrane currents participate in this phenomenon.

本研究确定了奎尼丁、维拉帕米、硝苯地平和哇巴因对清醒犬心房有效不应期（AERP）滞后现象的影响。2. 在额外刺激法中，AERP在递增期总是比递减期长，从而证明了AERP滞后现象的存在。滞后现象以两者之间的差值计算，为8±0.8至11±1.0毫秒。3. 奎尼丁使滞后现象从9±0.7毫秒增加到13±0.7毫秒，而维拉帕米使其从10±0.9毫秒减少到5±0.5毫秒，硝苯地平则无影响。哇巴因也使滞后现象从8±0.8毫秒延长到11±1.2毫秒。4. 因此，这些结果证实了清醒犬AERP中存在滞后现象，并且证明快速钠和慢速钙特异性膜电流参与了这一现象。

Boucher M, Chassaing C, Chapuy E, Lorente P

Department of Physiology, Faculty of Pharmacy, Clermont-Ferrand, France.

Gen Pharmacol. 1999 Jan;32(1):47-50. doi: 10.1016/s0306-3623(98)00056-1.

This work determines the effects of quinidine, verapamil, nifedipine and ouabain on the hysteresis of the atrial effective refractory period (AERP) in the conscious dog. 2. AERP was always longer in the increasing phase than in the decreasing phase of the extrastimulus method, thus demonstrating the existence of AERP hysteresis. Calculated as the difference between the two values, hysteresis was between 8+/-0.8 and 11+/-1.0 msec. 3. Quinidine increased hysteresis from 9+/-0.7 to 13+/-0.7 msec, whereas verapamil decreased it from 10+/-0.9 to 5+/-0.5 msec and nifedipine did not affect it. Ouabain also lengthened hysteresis from 8+/-0.8 to 11+/-1.2 msec. 4. Thus, these results confirm the existence of a hysteresis phenomenon in the AERP in the conscious dog and are evidence that the fast sodium and slow calcium specific membrane currents participate in this phenomenon.

本研究确定了奎尼丁、维拉帕米、硝苯地平和哇巴因对清醒犬心房有效不应期（AERP）滞后现象的影响。2. 在额外刺激法中，AERP在递增期总是比递减期长，从而证明了AERP滞后现象的存在。滞后现象以两者之间的差值计算，为8±0.8至11±1.0毫秒。3. 奎尼丁使滞后现象从9±0.7毫秒增加到13±0.7毫秒，而维拉帕米使其从10±0.9毫秒减少到5±0.5毫秒，硝苯地平则无影响。哇巴因也使滞后现象从8±0.8毫秒延长到11±1.2毫秒。4. 因此，这些结果证实了清醒犬AERP中存在滞后现象，并且证明快速钠和慢速钙特异性膜电流参与了这一现象。