Westerveld H E
Department of Internal Medicine, Academic Hospital Utrecht, The Netherlands.
Atherosclerosis. 1998 Dec;141 Suppl 1:S105-7. doi: 10.1016/s0021-9150(98)00227-5.
Women with angiographically proven coronary heart disease (CAD) had higher postprandial concentrations of small chylomicron-remnants, measured as IDL apo B48, than women without CAD. Fasting TG concentrations were not different and within the normal range. Thus, the postprandial concentration of small chylomicron-remnants could identify women at high CAD risk within a normolipidemic population. Replacement therapy with 17beta-estradiol improved the clearance of chylomicron-remnants by 41% and attenuated the postprandial reduction in HDL-cholesterol by 66%. This improvement in postprandial lipid metabolism can explain part of the protective effect of estrogens against CAD.
经血管造影证实患有冠心病（CAD）的女性，其餐后小乳糜微粒残粒的浓度（以IDL apo B48衡量）高于未患CAD的女性。空腹甘油三酯（TG）浓度无差异且在正常范围内。因此，小乳糜微粒残粒的餐后浓度可在血脂正常人群中识别出CAD高风险女性。17β - 雌二醇替代疗法使乳糜微粒残粒的清除率提高了41%，并使餐后高密度脂蛋白胆固醇（HDL - 胆固醇）的降低幅度减弱了66%。餐后脂质代谢的这种改善可以解释雌激素对CAD的部分保护作用。
