Ambrogi Lorenzini C G, Baldi E, Bucherelli C, Sacchetti B, Tassoni G
Dipartimento di Scienze Fisiologiche, Università degli Studi di Firenze, Viale G. B. Morgagni 63, Florence, I-50134, Italy.
Neurobiol Learn Mem. 1999 Jan;71(1):1-18. doi: 10.1006/nlme.1998.3865.
Findings on the role of subcortical and cortical structures in mnemonic processes, obtained by means of the reversible functional inactivation technique, are reviewed. The main advantage of this method (subcortical or cortical administration of local anesthetics or tetrodotoxin) is that it provides information not only on "where" but also "when" and for "how long" these processes take place, thus adding to the topographical dimension the chronological one. The review covers several types of memory (e.g., passive avoidance and spatial memory) studies examining the neural substrates of memory consolidation on the basis of the functional inactivation of the nucleus of the solitary tract, parabrachial nuclei, substantia nigra, hippocampus (dorsal and ventral), nucleus basalis magnocellularis, amygdala, medial septal area, striatum, olfactory bulb, and neocortex. The data are discussed in relation to earlier research and with respect to the anatomical and functional connectivity of the examined centers.
本文综述了通过可逆性功能失活技术获得的关于皮层下和皮层结构在记忆过程中作用的研究结果。该方法（皮层下或皮层注射局部麻醉剂或河豚毒素）的主要优点在于，它不仅能提供这些过程发生的“位置”信息，还能提供“时间”以及“持续时长”信息，从而在地形维度上增加了时间维度。该综述涵盖了几种类型的记忆（如被动回避和空间记忆）研究，这些研究基于对孤束核、臂旁核、黑质、海马体（背侧和腹侧）、大细胞基底核、杏仁核、内侧隔区、纹状体、嗅球和新皮层的功能失活，来探究记忆巩固的神经基础。文中结合早期研究以及所研究中心的解剖和功能连接性对这些数据进行了讨论。
