性染色体：不断进化的剂量补偿

Sex chromosomes: evolving dosage compensation.

作者信息

Charlesworth B

机构信息

Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 2BR, UK.

出版信息

Curr Biol. 1998;8(25):R931-3. doi: 10.1016/s0960-9822(98)00013-x.

DOI:10.1016/s0960-9822(98)00013-x

PMID:9889089

Abstract

Dosage compensation of some X-linked genes varies among mammals. Inactivation of an X-linked copy of a gene in females appears to correlate with lack of an active homologue on the Y chromosome, implying that dosage compensation evolves in response to the loss of function of genes on the Y.

摘要

某些X连锁基因的剂量补偿在哺乳动物中存在差异。雌性中一个基因的X连锁拷贝的失活似乎与Y染色体上缺乏活性同源物相关，这意味着剂量补偿是为响应Y染色体上基因功能的丧失而进化的。