Saunders N J, Moxon E R
Molecular Infectious Diseases Group Institute of Molecular Medicine University of Oxford Headington Oxford OX3 9DS UK.
Curr Opin Biotechnol. 1998 Dec;9(6):618-23. doi: 10.1016/s0958-1669(98)80140-7.
Improvements in homology search methodology and functional predictions are being complemented by the increase in the volume of sequence data with which comparative analyses can be performed. The experimental methods needed for investigation of gene function and expression in a variety of model systems of infection continue to develop. The identification of surface-exposed microbial structures and their conservation in natural populations of pathogenic species offers prospects for developing novel vaccines. A major challenge is the development of efficient screening methods to select the most promising candidates, such as immunisation with DNA.
同源性搜索方法和功能预测的改进，正因可用于进行比较分析的序列数据量的增加而得到补充。在多种感染模型系统中研究基因功能和表达所需的实验方法也在不断发展。对病原体自然种群中表面暴露的微生物结构及其保守性的鉴定，为开发新型疫苗提供了前景。一个主要挑战是开发有效的筛选方法，以挑选出最有前景的候选物，例如DNA免疫。
