Griffiths E
National Institute for Biological Standards and Control, Potters Bar, Herts, UK.
Trends Biotechnol. 1991 Sep;9(9):309-15. doi: 10.1016/0167-7799(91)90101-m.
There is now overwhelming evidence that many of the crucial virulence determinants of pathogenic bacteria are environmentally regulated and expressed only under certain conditions. Much progress is currently being made in identifying these factors and in understanding the molecular mechanisms controlling their production. This information is crucial for the understanding of microbial pathogenicity and it has important practical implications for vaccine design and production.
现在有大量证据表明，许多病原菌的关键毒力决定因素受环境调控，仅在特定条件下表达。目前在识别这些因素以及理解控制其产生的分子机制方面取得了很大进展。这些信息对于理解微生物致病性至关重要，并且对疫苗设计和生产具有重要的实际意义。
