理解复杂疾病特征的医学意义。

Medical implications of understanding complex disease traits.

作者信息

Bell J

机构信息

University of Oxford Level 7 John Radcliffe Hospital Headington Oxford OX3 9DU UK.

出版信息

Curr Opin Biotechnol. 1998 Dec;9(6):573-7. doi: 10.1016/s0958-1669(98)80134-1.

DOI:10.1016/s0958-1669(98)80134-1

PMID:9889146

Abstract

The application of genetic mapping to human disease gene identification has led to the definition of many linkages and a few disease genes in complex traits over the past two years. Its application has also increased to include aspects of pharmacogenetics relating to pharmacokinetics and pharmacodynamics.

摘要

在过去两年中，基因图谱在人类疾病基因识别中的应用已促成了许多复杂性状中的连锁关系的确定以及少数疾病基因的明确。其应用范围也已扩大到包括与药物代谢动力学和药效学相关的药物遗传学方面。