Bell J I
Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK.
Curr Opin Genet Dev. 1993 Jun;3(3):466-9. doi: 10.1016/0959-437x(93)90121-5.
Considerable success is now being achieved in defining genetic susceptibility loci in polygenic disease. In particular, new susceptibility loci have been identified in hypertension, type I and type II diabetes, asthma and malaria infection. The approaches and tools for mapping such susceptibility determinants are becoming more clearly defined and the identification of further susceptibility genes is likely to be in demand in the near future.
目前在确定多基因疾病的遗传易感性位点方面已取得了相当大的成功。特别是，在高血压、I型和II型糖尿病、哮喘以及疟疾感染中已发现了新的易感位点。绘制此类易感性决定因素的方法和工具正变得更加明确，并且在不久的将来可能需要鉴定更多的易感基因。
