Frye S V
Division of Chemistry Glaxo Wellcome Inc., 3.4134 5 Moore Drive Research Triangle Park NC 27709 USA.
Chem Biol. 1999 Jan;6(1):R3-7. doi: 10.1016/S1074-5521(99)80013-1.
Extension of the traditional pharmacological approach of protein target classification to whole target systems has the potential to relate elements of protein sequence to the structure-activity relationship (SAR) of small molecules that can modulate protein action. Grouping potential drug discovery targets into families based on the relatedness of their SAR provides a means to translate the information from genome-sequencing efforts into knowledge that will aid in the discovery of drugs.
将传统的蛋白质靶点分类药理学方法扩展到整个靶点系统，有可能将蛋白质序列的元素与能够调节蛋白质作用的小分子的构效关系（SAR）联系起来。根据潜在药物发现靶点的SAR相关性将其分组为家族，提供了一种将基因组测序工作中的信息转化为有助于药物发现的知识的方法。
