Taha H, Irfan S, Krishnamurthy M
Department of Medicine, New York Methodist Hospital, Brooklyn, USA.
Head Neck. 1999 Jan;21(1):78-9. doi: 10.1002/(sici)1097-0347(199901)21:1<78::aid-hed11>3.0.co;2-7.
Bilateral vocal cord paralysis is uncommon. Most cases occur secondary to trauma, malignancy, surgery, or intubation. Also, it was reported as a side effect of Vinca alkaloids.
We report a patient with small cell lung cancer who developed bilateral vocal cord paralysis and needed to be intubated after treatment with cisplatin and etoposide. All workups excluded metastases as a cause of bilateral vocal cord paralysis. The patient required tracheostomy; she did not receive any further chemotherapy. After 11 weeks, vocal cord paralysis disappeared, tracheostomy was reversed, and the patient remained symptom free; however, 6 months later, the patient developed brain and liver metastases and died from her disease with no evidence of vocal cord paralysis.
We report a case of reversible bilateral vocal cord paralysis that we believe to be secondary to cisplatin toxicity, which is an undescribed complication of this drug.
Cisplatin can induce reversible bilateral vocal cord paralysis. The concurrent use of cisplatin and etoposide might have contributed to this complication in our patient.
双侧声带麻痹并不常见。大多数病例继发于创伤、恶性肿瘤、手术或插管。此外，曾有报道称其为长春花生物碱的副作用。
我们报告一例小细胞肺癌患者，在接受顺铂和依托泊苷治疗后出现双侧声带麻痹，需要进行插管。所有检查均排除转移是双侧声带麻痹的病因。该患者需要行气管切开术；她未再接受任何化疗。11周后，声带麻痹消失，气管切开术恢复，患者无症状；然而，6个月后，患者出现脑和肝转移，死于疾病，未发现声带麻痹迹象。
我们报告一例可逆性双侧声带麻痹病例，我们认为这是顺铂毒性所致，这是该药物一种未被描述的并发症。
顺铂可诱发可逆性双侧声带麻痹。顺铂和依托泊苷的同时使用可能导致了我们这位患者出现此并发症。
