Naschitz J E, Bejar J, Mogilner J, Misselevich I, Steiner Z, Eldar S, Yeshurun D, Boss J H
Department of Internal Medicine A, Bnai-Zion Medical Center and The Bruce Rapapport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
J Dermatol Sci. 1999 Jan;19(1):9-16. doi: 10.1016/s0923-1811(98)00042-5.
The authors studied the effect of ligation of the femoral and saphenous veins on the evolution of lipase injection-induced subcutaneous fibrosis and inflammation in the rats' hindlimbs. The superficial muscular fascia was thickened and the number of veins was increased 3 days and 3 weeks after vein ligation; both abnormalities disappeared 6 weeks postoperatively. Vein ligation did not quantitatively affect fascial thickening or fibrosing panniculitis in hindlimbs injected with lipase 6 weeks prior to sacrifice. The results contradict the proposition that lipase-induced injury of rats' subcutaneous tissues compromised by venous stasis may lead to a persistent chronic inflammation and fibrosis of the subcutaneous-fascial complex duplicating lipodermatosclerosis in man.
作者研究了结扎股静脉和隐静脉对大鼠后肢注射脂肪酶所致皮下纤维化和炎症演变的影响。静脉结扎后3天和3周，浅肌筋膜增厚，静脉数量增加；术后6周，这两种异常均消失。在处死前6周注射脂肪酶的后肢，静脉结扎并未对筋膜增厚或脂肪性纤维炎产生定量影响。这些结果与以下观点相矛盾，即脂肪酶诱导的大鼠皮下组织损伤在静脉淤滞的影响下，可能导致皮下-筋膜复合体持续慢性炎症和纤维化，类似于人类的脂肪皮肤硬化症。
