Aziz S A, Tramboo N A, Mohi-ud-Din K, Iqbal K, Jalal S, Ahmad M
Sheri Kashmir Institute of Medical Sciences, Srinagar, India.
Clin Oncol (R Coll Radiol). 1998;10(6):377-8. doi: 10.1016/s0936-6555(98)80033-2.
5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens. Gastrointestinal toxicity and myelosuppression are the most common adverse reactions, but, of late, clinical cardiotoxicity has been reported in both prospective and retrospective studies. We present our experience of clinical cardiotoxicity in five patients.
5-氟尿嘧啶是一种S期特异性的合成嘧啶抗代谢物，可单独或与多种药物联合用作多种恶性病变的细胞抑制剂。胃肠道毒性和骨髓抑制是最常见的不良反应，但最近，前瞻性和回顾性研究均报道了临床心脏毒性。我们介绍了5例患者临床心脏毒性的经验。
