Terao K, Kera K, Yazima T
Virchows Arch B Cell Pathol. 1978 Jun 19;27(4):359-70. doi: 10.1007/BF02889007.
The effects of T-2 toxin, Fusarenon X (FX), and Nivalenol (NV) on the bursa of Fabricius in the day-old chick were examined. After injections of 5 mg/kg of the mycotoxins into the residual yolk sac, cellular injury was limited at first to the smaller epithelial cells with coarse microvilli, which were located in the central portion of the follicle-associated epithelium. Subsequently necrosis spread out to the periphery. Degeneration and necrosis followed in the lymphoid cells in the lymphoid follicles. The other epithelial components in the follicle were relatively resistant to the mycotoxins. Both FX and NV were less potent than T-2 toxin, although the effects on the bursa of Fabricius were essentially the same. These findings suggest that the follicle-associated epithelium is clearly distinguished from other epithelial components in the bursa of Fabricius in day-old chicks.
研究了T-2毒素、镰刀菌烯醇X（FX）和雪腐镰刀菌烯醇（NV）对一日龄雏鸡法氏囊的影响。将5mg/kg的霉菌毒素注射到残留卵黄囊中后，细胞损伤最初局限于卵泡相关上皮中央部分具有粗大微绒毛的较小上皮细胞。随后坏死扩散到周边。淋巴滤泡中的淋巴细胞随后发生变性和坏死。卵泡中的其他上皮成分对霉菌毒素相对有抵抗力。尽管FX和NV对法氏囊的影响基本相同，但它们的效力均低于T-2毒素。这些发现表明，在一日龄雏鸡中，卵泡相关上皮与法氏囊中的其他上皮成分明显不同。
