Guarino M, Casmiro M, D'Alessandro R
Institute of Neurology, Neuroepidemiology Unit, via Foscolo, 7 Bologna,Italy.
Neuroepidemiology. 1998;17(6):296-302. doi: 10.1159/000026183.
We performed a case-control study to investigate the association between Campylobacter jejuni (CJ) infection and Guillain-Barr| syndrome (GBS) or Miller-Fisher syndrome. We compared 60 cases with 109 hospital controls matched for age, gender, hospital and geographical location. To diagnose the CJ infection, we considered the association between serologic positivity for CJ and a previous diarrheal illness within 3 months of inclusion in the study. Fifteen percent of cases versus 5% of hospital controls had CJ infection (p < 0.003, OR = 3.96, 95% CI: 1.0817.85). However, CJ infection was related to GBS only if it occurred during the previous month (p< 0.001, OR = 7.29, 95% CI: 1.4371.28). No statistical differences were found between the cases who were positive for CJ infection and those who were negative for CJ infection when studied by stepwise multivariate logistic regression for age, gender, clinical and electrophysiological features and outcome. Recent CJ infection may be a risk factor for GBS.
我们进行了一项病例对照研究，以调查空肠弯曲菌（CJ）感染与吉兰 - 巴雷综合征（GBS）或米勒 - 费雪综合征之间的关联。我们将60例病例与109例医院对照进行比较，这些对照在年龄、性别、医院和地理位置方面相匹配。为诊断CJ感染，我们考虑了CJ血清学阳性与纳入研究前3个月内既往腹泻病之间的关联。15%的病例与5%的医院对照有CJ感染（p < 0.003，OR = 3.96，95%CI：1.08 - 17.85）。然而，仅当CJ感染发生在前一个月时才与GBS相关（p < 0.001，OR = 7.29，95%CI：1.43 - 71.28）。当按年龄、性别、临床和电生理特征及结局进行逐步多因素逻辑回归分析时，CJ感染阳性的病例与CJ感染阴性的病例之间未发现统计学差异。近期CJ感染可能是GBS的一个危险因素。
