Nelson J D, Mohs E, Dajani A S, Plotkin S A
JAMA. 1976 Sep 20;236(12):1359-64. doi: 10.1001/jama.236.12.1359.
Single-dose antibiotic therapy was evaluated in 108 episodes of culture-confirmed, uncomplicated gonorrhea in 100 prepubertal children. There were 15 boys and 85 girls between 14 months and 14 years of age. Penicillin G procaine, 100,000 units/kg intramuscularly, was compared with amoxicillin trihydrate, 50 mg/kg orally. Probenecid, 25 mg/kg, was given simultaneously. Both drugs provided prompt bacteriological and clinical response. Multiple episodes of gonorrhea, presumably caused by reexposure, occurred in six girls. Oral and anal cultures were negative in all of 47 Costa Rican cases but were commonly positive in US children. Anal cultures yielded gonococci in 52% of girls and 25% of boys, and oral cultures were positive in 18% and 13%, respectively. In three instances, rectal cultures confirmed the diagnosis when vaginal cultures were negative. Gonorrhea should be considered in every child with vaginal or urethral discharge. Single-dose penicillin-probenecid or amoxicillin-probenecid treatment is curative.
对100名青春期前儿童的108例经培养确诊的无并发症淋病病例进行了单剂量抗生素治疗评估。患儿年龄在14个月至14岁之间，其中有15名男孩和85名女孩。将肌肉注射100,000单位/千克的普鲁卡因青霉素G与口服50毫克/千克的三水阿莫西林进行比较。同时给予25毫克/千克的丙磺舒。两种药物均能迅速产生细菌学和临床反应。6名女孩出现了可能因再次接触而导致的多次淋病发作。在47例哥斯达黎加病例中，所有病例的口腔和肛门培养均为阴性，但在美国儿童中通常为阳性。肛门培养在52%的女孩和25%的男孩中检出淋球菌，口腔培养的阳性率分别为18%和13%。在3例病例中，当阴道培养为阴性时，直肠培养确诊了淋病。对于每一名有阴道或尿道分泌物的儿童都应考虑淋病。单剂量青霉素-丙磺舒或阿莫西林-丙磺舒治疗是有效的。
