Ravid M, Robson M
JAMA. 1976 Sep 20;236(12):1380-1.
Severe proximal myopathy associated with hypophosphatemia developed in three patients with chronic renal failure who had been treated with aluminum hydroxide gel. The syndrome was characterized by severe pain, muscular stiffness, and weakness. The illness was originally misdiagnosed both as uremic myopathy and as an exacerbation of rheumatoid arthritis. In one patient, the correct diagnosis was made when symptomatic relief corresponded to the rise of serum phosphate levels. Discontinuation of antacid therapy was followed by gradual recovery. Oral sodium phosphate brought prompt alleviation of muscular pain and stiffness.
三名接受氢氧化铝凝胶治疗的慢性肾衰竭患者出现了与低磷血症相关的严重近端肌病。该综合征的特点是严重疼痛、肌肉僵硬和无力。这种疾病最初被误诊为尿毒症肌病和类风湿关节炎加重。在一名患者中，当症状缓解与血清磷酸盐水平升高相对应时做出了正确诊断。停止抗酸治疗后病情逐渐恢复。口服磷酸钠可迅速缓解肌肉疼痛和僵硬。
