Evans A, Lytwyn A, Urbach G, Chapman W
Department of Pathology, Women's College Hospital, Toronto, Ontario, Canada.
Int J Gynecol Pathol. 1999 Jan;18(1):87-90. doi: 10.1097/00004347-199901000-00014.
Lymphangiomas of the ovary are rare tumors, with only 13 cases reported. The diagnoses of these tumors have been based on histologic findings without immunohistochemical confirmation of endothelial cell origin. It is uncertain if these tumors are true neoplasms or if some represent reactive lesions. In this report, the literature is reviewed, and a 53-year-old woman with bilateral ovarian lymphangiomas is described. The ovarian masses were composed of numerous, thin-walled, cystic spaces containing a proteinaceous fluid, mature lymphocytes, and occasional erythrocytes. The cyst walls were lined by flat, benign-appearing cells that were immunoreactive for factor VIII-related antigen, CD34, and CD31. Further examination of the specimen showed absent fallopian tube fimbriae, tuboovarian adhesions, and chronic follicular salpingitis, suggesting that the lymphatic proliferation in the ovaries was a reactive change secondary to impaired regional lymphatic drainage.
卵巢淋巴管瘤是罕见肿瘤，仅报道过13例。这些肿瘤的诊断基于组织学发现，未经内皮细胞起源的免疫组化证实。这些肿瘤是否为真正的肿瘤，或者有些是否代表反应性病变尚不确定。在本报告中，回顾了相关文献，并描述了一名患有双侧卵巢淋巴管瘤的53岁女性。卵巢肿块由众多薄壁囊性间隙组成，内含蛋白质样液体、成熟淋巴细胞及偶尔的红细胞。囊肿壁内衬扁平、看似良性的细胞，这些细胞对因子VIII相关抗原、CD34和CD31呈免疫反应性。对标本的进一步检查显示输卵管伞端缺如、输卵管卵巢粘连及慢性滤泡性输卵管炎，提示卵巢中的淋巴组织增生是局部淋巴引流受损继发的反应性改变。
