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关于7,12 - 二甲基苯并蒽对大鼠肾上腺皮质内层的肾上腺溶解作用机制的高分辨率放射自显影研究。

High resolution autoradiographic investigations on the mechanism of the adrenolytic effect of 7,12-dimethylbenzanthracene on the inner layers of the rat adrenal cortex.

作者信息

Mazzocchi G, Belloni A S, Robba C, Nussdorfer G G

出版信息

Virchows Arch B Cell Pathol. 1978 Aug 25;28(2):97-104. doi: 10.1007/BF02889061.

DOI:10.1007/BF02889061
PMID:98913
Abstract

The effects of chronic treatment with DMBA on the 3H-uridine incorporation into rat adrenocortical cells was investigated by high resolution autoradiography. It was found that DMBA significantly decreases the tracer incorporation into both nuclear and mitochondrial compartments of the zona reticularis cells. The hypothesis that the mechanism of the lytic effect of DMBA on the inner adrenocortical layers involves inhibition of nuclear and mitochondrial RNA synthesis is discussed.

摘要

通过高分辨率放射自显影术研究了二甲基苯并蒽（DMBA）长期处理对3H-尿苷掺入大鼠肾上腺皮质细胞的影响。结果发现，DMBA显著降低了示踪剂掺入网状带细胞的细胞核和线粒体部分。本文讨论了DMBA对肾上腺皮质内层的溶解作用机制涉及抑制细胞核和线粒体RNA合成的假说。

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