Amlacher E, Danz M
Exp Pathol (Jena). 1975;10(5-6):338-47. doi: 10.1016/s0014-4908(75)80042-1.
In CBA-mice the competition of DENA and DMBA was studied by quantitative autoradiography. During the precancerous phase in DENA-pretreated animals the rate of DMBA-incorporation into DNA/RNA and nuclear proteins was lower as compared to the controls without DENA-pretreatment. Independent of DENA-pretreatment the rate of DMBA-incorporation into the cytoplasm was significantly enhanced in hepatectomized animals. In this experiment the skin as a target organ did not show any quantitatively measurable DMBA-incorporation despite of prolonged autoradiographic exposition time.
在CBA小鼠中，通过定量放射自显影研究了二乙基亚硝胺（DENA）和二甲基苯并蒽（DMBA）的竞争情况。在DENA预处理动物的癌前阶段，与未进行DENA预处理的对照组相比，DMBA掺入DNA/RNA和核蛋白中的速率较低。无论是否进行DENA预处理，肝切除动物中DMBA掺入细胞质的速率均显著提高。在本实验中，尽管放射自显影曝光时间延长，但作为靶器官的皮肤未显示出任何可定量测量的DMBA掺入情况。
