Kondashevskaia M V, Liapina L A
Moscow State University, Faculty of Biology, Moscow, Russia.
Izv Akad Nauk Ser Biol. 1998 Nov-Dec(6):758-61.
High-molecular-weight heparin-piracetam complex (1:1 w/w ratio) was obtained in vitro. The complex, its components, or physiological solution were introduced intraperitoneally in rats (0.3 ml, 0.1%). Piracetam had no effect on homeostasis. The heparin-piracetam complex had a more pronounced anticoagulant and fibrinolytic activities than the individual components. In addition, this complex accelerated blood flow in the brain. In conditions of acute hypoxia (a 12,000-m altitude chamber), heparin protected animals from hypoxia more effectively than other substances.
在体外获得了高分子量肝素 - 吡拉西坦复合物(重量比为1:1)。将该复合物、其组分或生理溶液经腹腔注射给大鼠(0.3毫升,0.1%)。吡拉西坦对体内平衡没有影响。肝素 - 吡拉西坦复合物比其单个组分具有更显著的抗凝和纤溶活性。此外,该复合物可加速脑内血流。在急性缺氧条件下(12000米高度舱),肝素比其他物质更有效地保护动物免受缺氧影响。