Gebel T, Birkenkamp P, Luthin S, Dunkelberg H
Medical Institute of General Hygiene and Environmental Health, University of Goettingen, Germany.
Anticancer Res. 1998 Nov-Dec;18(6A):4253-7.
Antimony compounds are supposed to resemble to arsenicals in some toxicological features. Comparative investigations with antimony and arsenic were performed to collect data on the genotoxicity of antimony, on which the knowledge is scarce. In comparison to trivalent arsenic, trivalent antimony proved to be five times less cytotoxic in the neutral red assay and one order of magnitude less genotoxic in the cytokinesis-block micronucleus test using V79 Chinese hamster cells. The data obtained in the comet assay showed that the As(III)-mediated generation of DNA-protein crosslinks and DNA strand lesions seem to be two independent processes. In contrast, Sb(III) induced DNA strand lesions but not DNA-protein crosslinks. Further studies will have to investigate whether the genotoxicity of Sb(III) is mediated by an inhibition of DNA repair as it seems to be the case for As(III).
锑化合物在某些毒理学特性上被认为与砷化合物相似。对锑和砷进行了比较研究，以收集关于锑的遗传毒性的数据，而这方面的知识还很匮乏。与三价砷相比，在中性红试验中，三价锑的细胞毒性低五倍，在使用V79中国仓鼠细胞的胞质分裂阻滞微核试验中，其遗传毒性低一个数量级。彗星试验获得的数据表明，As(III)介导的DNA-蛋白质交联和DNA链损伤的产生似乎是两个独立的过程。相比之下，Sb(III)诱导了DNA链损伤，但没有诱导DNA-蛋白质交联。进一步的研究将不得不调查Sb(III)的遗传毒性是否像As(III)那样是由DNA修复的抑制介导的。
