Kurtz A, Wagner C
Physiologisches Institut der Universität Regensburg, Germany.
J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S162-8.
Angiotensin II (AngII) resulting as the end product of a proteolytic cascade initiated by renin inhibits the secretion of renin in the sense of a negative feedback. A direct effect of AngII on renal juxtaglomerular epithelioid cells as the main source of renin secretion is mediated via AngII-AT1 receptors and involves calcium-dependent reactions. These reactions may comprise activation of protein kinase C and activation of chloride channels.
