DiBona G F
Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City 52242, USA.
J Am Soc Nephrol. 1999 Jan;10 Suppl 11:S90-4.
The role of the renin-angiotensin system in the control of sympathetic nerve activity is reviewed. Two general mechanisms are considered, one that involves the effects of circulating angiotensin II (AngII) on the central nervous system and a second that involves the central nervous system effects of AngII that originates within the central nervous system. The role of type 1 AngII receptors in discrete brain sites that mediate the sympathoexcitatory actions of AngII of either circulating or central nervous system origin is examined. AngII of circulating origin has ready access to the subfornical organ and area postrema, where it can bind to type 1 AngII receptors on neurons whose connections to the nucleus tractus solitarius and rostral ventrolateral medulla result in sympathoexcitation. In the rostral ventrolateral medulla, angiotensin peptides of central nervous system origin, likely involving angiotensin species in addition to AngII and binding to receptors other than type 1 or 2 AngII receptors, tonically support sympathetic nerve activity.
本文综述了肾素-血管紧张素系统在控制交感神经活动中的作用。文中考虑了两种一般机制，一种涉及循环中的血管紧张素II（AngII）对中枢神经系统的作用，另一种涉及源自中枢神经系统的AngII对中枢神经系统的作用。研究了1型AngII受体在离散脑区中的作用，这些脑区介导循环或中枢神经系统来源的AngII的交感兴奋作用。循环来源的AngII可轻易进入穹窿下器官和最后区，在那里它可以与神经元上的1型AngII受体结合，这些神经元与孤束核和延髓头端腹外侧的连接会导致交感兴奋。在延髓头端腹外侧，中枢神经系统来源的血管紧张素肽，可能除了AngII之外还涉及其他血管紧张素种类，并与1型或2型AngII受体以外的受体结合，持续支持交感神经活动。
