Geracioti T D, West S A, Baker D G, Hill K K, Ekhator N N, Wortman M D, Keck P E, Norman A B
Department of Psychiatry, University of Cincinnati Medical Center, OH, USA.
Am J Psychiatry. 1999 Jan;156(1):130-2. doi: 10.1176/ajp.156.1.130.
To screen for dopaminergic abnormalities in tobacco smokers and patients with posttraumatic stress disorder (PTSD), the authors determined serial CSF and plasma concentrations of the dopamine metabolite homovanillic acid (HVA).
Continuous subarachnoid sampling was used to obtain 37 serial CSF samples over 6 hours in 13 normal volunteers and 11 patients with combat-related PTSD; 10 smoked and 14 had never smoked. The smokers were abstinent from tobacco for 1 1 to 17 hours.
The smokers had markedly lower CSF, but not plasma, HVA levels. Their CSF HVA concentrations averaged only 54% of the concentrations of the nonsmokers, independent of diagnosis.
Smokers' low CSF concentrations of HVA may be associated either with chronic inhalation of nicotine or other constituents of tobacco smoke or with acute abstinence. Any possible basal dopaminergic abnormalities in patients with PTSD are small relative to the abnormalities associated with smoking.
为筛查吸烟者和创伤后应激障碍（PTSD）患者的多巴胺能异常情况，作者测定了多巴胺代谢产物高香草酸（HVA）在脑脊液（CSF）和血浆中的系列浓度。
对13名正常志愿者和11名与战斗相关的PTSD患者采用连续蛛网膜下腔采样法，在6小时内获取37份系列CSF样本；其中10人吸烟，14人从不吸烟。吸烟者戒烟11至17小时。
吸烟者的CSF中HVA水平显著降低，但血浆中HVA水平未降低。无论诊断如何，他们CSF中HVA浓度平均仅为不吸烟者浓度的54%。
吸烟者CSF中HVA浓度低可能与长期吸入尼古丁或烟草烟雾中的其他成分有关，也可能与急性戒烟有关。与吸烟相关的异常相比，PTSD患者任何可能的基础多巴胺能异常都较小。
