Higher levels of CSF homovanillic acid in recently abstinent cocaine-dependent patients.
作者信息
Roy Alec, Berman Jeffrey, Williams Redford, Kuhn Cynthia, Gonzalez Bienvenido
机构信息
Psychiatric Services, Department of Veterans Affairs, New Jersey Health Care System, East Orange, 07018, USA.
出版信息
Am J Psychiatry. 2002 Jun;159(6):1053-5. doi: 10.1176/appi.ajp.159.6.1053.
OBJECTIVE
The authors examined an index of dopaminergic neurotransmission in recently abstinent cocaine-dependent patients.
METHOD
CSF concentrations of the dopamine metabolite homovanillic acid (HVA) were determined in 30 recently abstinent cocaine-dependent patients and 69 healthy comparison subjects.
RESULTS
The cocaine-dependent patients had a significantly higher mean concentration of CSF HVA than did the healthy comparison group.
CONCLUSIONS
Recently abstinent cocaine-dependent patients may show dysregulation of the central dopaminergic system.
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