Assmann I, Schwela H, Oltmanns G, Fiehring H
Z Gesamte Inn Med. 1978 May 15;33(10):300-3.
The effect of the Ca++ -antagonist Verapamil on the ECG, the haemodynamic parameters and the systolic time intervals was investigated in the long-term experiment on 12 patients with ascertained chronic ischaemic heart disease at reat and during exercise. The dosage was 3 x 80 mg/die during 4 weeks. The tolerance was not increased. The load-induced decrease of the ST-T-distance in the ECG was improved under load and in the recreation phase. The function of the myocardium, measured on the quotient LVET/ICT, improved under load with simultaneous decrease of the double product and the TTI, the pulmonary pressure, however, remained uninfluenced. Side-effects were not observed.
在12例确诊为慢性缺血性心脏病且处于静息及运动状态的患者身上进行了长期实验，研究了钙离子拮抗剂维拉帕米对心电图、血流动力学参数及收缩期时间间期的影响。剂量为每日3次，每次80毫克，持续4周。耐受性未增加。负荷诱发的心电图中ST段与T波间距缩短在负荷及恢复阶段均有所改善。以左室射血时间与等容收缩时间比值衡量的心肌功能在负荷状态下得到改善，同时双乘积和张力-时间指数下降，而肺动脉压未受影响。未观察到副作用。
