Ogashiwa M, Takeuchi K
Acta Neurochir (Wien). 1976;34(1-4):37-44. doi: 10.1007/BF01405861.
A study was made of intrathecal infusion as a route for administration of drugs for the CNS. We recognize the presence of blood brain and CSF brain barriers. CDP-choline was used as the brain activator, and the effect of the intrathecally infused drug was investigated clinically. Fifteen patients with disturbances of consciousness due to primary cerebral lesions received a total of 39 intrathecal infusions of CDP-choline, and were examined neurologically and electroencephalographically before and after treatment.
一项关于鞘内注射作为中枢神经系统给药途径的研究。我们认识到血脑屏障和脑脊液脑屏障的存在。使用胞二磷胆碱作为脑激活剂，并对鞘内注射药物的效果进行了临床研究。15例因原发性脑损伤导致意识障碍的患者共接受了39次鞘内注射胞二磷胆碱，并在治疗前后进行了神经学和脑电图检查。
