Panin V M, Irvine K D
Department of Molecular Biology and Biochemistry, The State University, Rutgers, Piscataway, NJ 08854, USA.
Semin Cell Dev Biol. 1998 Dec;9(6):609-17. doi: 10.1006/scdb.1998.0263.
In addition to the core components of the Notch pathway, a number of proteins have been identified that exert positive or negative influences on Notch signaling. These include extracellular modulators, which may influence binding or activation of Notch by its ligands, cytoplasmic modulators, which presumably influence signal transduction steps after receptor activation, and nuclear modulators, which may influence the transcriptional activity of a Notch-CSL protein complex. Many of the cytoplasmic and nuclear modulators appear to bind directly to discrete domains within the intracellular domain of Notch. Genetic studies indicate that distinct modulators are deployed during distinct modes of Notch signaling.
除了Notch信号通路的核心组件外，还鉴定出了许多对Notch信号传导产生正向或负向影响的蛋白质。这些包括细胞外调节剂，其可能影响Notch与其配体的结合或激活；细胞质调节剂，其可能影响受体激活后的信号转导步骤；以及核调节剂，其可能影响Notch-CSL蛋白复合物的转录活性。许多细胞质和核调节剂似乎直接与Notch细胞内结构域内的离散结构域结合。遗传学研究表明，在不同的Notch信号传导模式中会部署不同的调节剂。
