Bray S
Department of Anatomy, Cambridge, UK.
Semin Cell Dev Biol. 1998 Dec;9(6):591-7. doi: 10.1006/scdb.1998.0262.
Cell-cell interactions mediated by Notch are critical at multiple stages of development. Our current understanding of the Notch signalling pathway suggests a comparatively simple transduction mechanism. However, this core pathway can be deployed in three different types of developmental process: lateral inhibition, lineage decisions and boundary formation. These illustrate how the activity of the pathway can be modulated both at the cell surface, through availability and effectiveness of ligand interactions, and inside the cell, through effects on the transduction pathway and the responsiveness of target genes.
由Notch介导的细胞间相互作用在发育的多个阶段至关重要。我们目前对Notch信号通路的理解表明其转导机制相对简单。然而，这条核心通路可应用于三种不同类型的发育过程：侧向抑制、谱系决定和边界形成。这些说明了该通路的活性如何在细胞表面通过配体相互作用的可用性和有效性进行调节，以及在细胞内通过对转导通路和靶基因反应性的影响进行调节。
