Al-Waili N S, Saloom K Y
Dubai Medical College and Dubai Medical Center for Treatment and Research, Islamic Establishment for Education, P.O. Box 19964, Dubai, United Arab Emirates.
Eur J Med Res. 1999 Jan 26;4(1):23-6.
To study the therapeutic effects of a single 40 mg intramuscular dose of piroxicam versus a single 75 mg intramuscular dose of diclofenac sodium for treatment of acute renal colic. - The study comprised 64 patients (52 men and 12 women, mean age 28 years, range 18 - 42) who presented with acute renal colic and were diagnosed by IVU, a general urine examination and ultrasonography. The patients were randomly assigned to receive either 40 mg of piroxicam i.m (34 patients) or 75 mg of diclofenac sodium i.m (330 patients). The severity of pain was assessed on Visual Analogue Scale. - Results showed that thirty-two patients (94.1%) markedly improved within 1h of receiving piroxicam and 26 patients (86.6%) improved within 1h of receiving diclofenac sodium (P <0.05). Within 30 min, 25 patients (73.5%) markedly improved after piroxicam and 15 patients (50%) markedly improved after diclofenac sodium (P <0.05). After piroxicam, none of the patients showed pain relapse over a period of 24 h while 9 patients had relapse within 24 h after their initial response to diclofenac sodium. No side effects were reported with use of either treatment. - We concluded that piroxicam can be used successfully to treat acute renal colic and it has earlier onset of action and prolong effect as compared with diclofenac sodium.
研究单次肌内注射40毫克吡罗昔康与单次肌内注射75毫克双氯芬酸钠治疗急性肾绞痛的疗效。——该研究纳入了64例患者（52例男性和12例女性，平均年龄28岁，范围18 - 42岁），这些患者表现为急性肾绞痛，并通过静脉肾盂造影（IVU）、尿常规检查和超声检查确诊。患者被随机分配接受40毫克吡罗昔康肌内注射（34例患者）或75毫克双氯芬酸钠肌内注射（30例患者）。采用视觉模拟评分法评估疼痛程度。——结果显示，32例患者（94.1%）在接受吡罗昔康后1小时内疼痛明显改善，26例患者（86.6%）在接受双氯芬酸钠后1小时内疼痛改善（P<0.05）。30分钟内，25例患者（73.5%）在接受吡罗昔康后疼痛明显改善，15例患者（50%）在接受双氯芬酸钠后疼痛明显改善（P<0.05）。使用吡罗昔康后，24小时内无患者疼痛复发，而26例患者在首次对双氯芬酸钠有反应后24小时内有9例复发。两种治疗方法均未报告有副作用。——我们得出结论，吡罗昔康可成功用于治疗急性肾绞痛，与双氯芬酸钠相比，其起效更早且作用持续时间更长。
