Muck B R, Hommel G
Arch Gynakol. 1976;221(1):61-72. doi: 10.1007/BF00667682.
Blood glucose and plasma insulin were measured during an intravenous glucose tolerance test (0.33 g/kg body weight) performed on 75 subjects. Various types of oral contraceptives were taken for an average period of 6.5 yrs. The cases were divided into several groups in order to examine the effect of combination-type drugs (group A; n= 40) and sequential-type drugs (group B; n = 23) separately. A third group had used both types of drugs (group C; n = 13). Fifteen women who have never taken hormone drugs served as control group. It was found that plasma insulin levels, blood glucose and k-values were not significantly elevated in the drug treated groups. The duration of treatment does not seem to have an effect on glucose tolerance and insulin secretion. In this study the patient's age is the most important associated data, and not overweight, family history of diabetes or past obstetric history. No statistical change in insulin levels, reaction areas of glucose and insulin after IVGTT was seen in any drug treated group.
对75名受试者进行静脉葡萄糖耐量试验（0.33克/千克体重）期间测量了血糖和血浆胰岛素。各种类型的口服避孕药平均服用6.5年。为了分别检查复方制剂（A组；n = 40）和序贯制剂（B组；n = 23）的效果，将病例分为几组。第三组同时使用了这两种类型的药物（C组；n = 13）。15名从未服用过激素药物的女性作为对照组。结果发现，药物治疗组的血浆胰岛素水平、血糖和k值没有显著升高。治疗持续时间似乎对葡萄糖耐量和胰岛素分泌没有影响。在本研究中，患者年龄是最重要的相关数据，而非超重、糖尿病家族史或既往产科病史。在任何药物治疗组中，静脉葡萄糖耐量试验后胰岛素水平、葡萄糖和胰岛素反应面积均无统计学变化。
