Llena J F, Céspedes G, Hirano A, Zimmerman H M, Feiring E H, Fine D
Arch Pathol Lab Med. 1976 Oct;100(10):531-4.
A 51-year-old woman who had been given cobalt therapy for nasopharyngeal carcinoma was seen three years later with a mass in the left frontotemporal region of the brain. Biopsy specimen of the lesion showed the classic features of delayed radiation necrosis on light microscopy. In addition, several blood vessels showed endothelial cell proliferation. Transmission electron microscopical study demonstrated numerous alterations of the endothelial cell, such as intraluminal infoldings of the plasma membrane, an increased amount of cytoplasmic organelles, and the frequent occurrence of tubular bodies in addition to degenerative and reactive changes in the neuropil.
一名曾因鼻咽癌接受钴治疗的51岁女性，三年后被发现脑部左额颞区有一肿块。病变的活检标本在光学显微镜下显示出迟发性放射性坏死的典型特征。此外，几根血管显示出内皮细胞增殖。透射电子显微镜研究表明内皮细胞有许多改变，如质膜的腔内褶皱、细胞质细胞器数量增加、频繁出现管状小体，以及神经纤维网的退行性和反应性变化。
