Grandaliano G, Gesualdo L, Schena F P
Institute of Nephrology, University of Bari, Italy.
Exp Nephrol. 1999 Jan-Feb;7(1):20-5. doi: 10.1159/000020580.
Glomerular fibrin deposition is a common histopathological finding in a variety of glomerular diseases and suggests the intraglomerular activation of the coagulation system. The activation of thrombin is the last step in the coagulation cascade. On the basis of its ability to modulate several cell functions through the activation of different receptors and intracellular-signaling pathways, thrombin could be considered as a growth factor more than as a simple coagulation factor. Indeed, this multifunctional serine protease may represent the link between the activation of the coagulation cascade and the inflammatory and profibrotic response at the glomerular level. This review will focus on the potential role of thrombin in the pathogenesis of glomerular damage and on the mechanisms underlying the cellular effects of this serine protease.
肾小球纤维蛋白沉积是多种肾小球疾病常见的组织病理学表现，提示肾小球内凝血系统被激活。凝血酶的激活是凝血级联反应的最后一步。基于其通过激活不同受体和细胞内信号通路来调节多种细胞功能的能力，凝血酶与其说是一种简单的凝血因子，不如说是一种生长因子。实际上，这种多功能丝氨酸蛋白酶可能是凝血级联反应激活与肾小球水平的炎症和纤维化反应之间的联系。本综述将聚焦于凝血酶在肾小球损伤发病机制中的潜在作用，以及这种丝氨酸蛋白酶细胞效应的潜在机制。
