Adler S
Am J Physiol. 1992 May;262(5 Pt 2):F697-704. doi: 10.1152/ajprenal.1992.262.5.F697.
The extracellular matrix (ECM) exerts important effects on cell function that play a vital role in such diverse processes as embryogenesis, wound healing, cancer metastasis, and inflammation. Interactions between cells and matrix are mediated by a variety of cell surface receptors for different components of the ECM. The integrin family of matrix receptors, the best-studied group thus far, has already been shown to play an important role in cell-matrix and cell-cell interactions in other systems. More recently, the types of integrin receptors present in the glomerulus and on cultured glomerular cells have been defined, and their potential involvement in glomerular injury has been postulated. This review will summarize current knowledge of integrin receptors, their distribution in the kidney, cultured glomerular cell-matrix interactions that might play a role in modulating the glomerular cell response to injury, and the potential role of integrins and other glomerular cell matrix receptors as targets of injury in proteinuric lesions.
细胞外基质（ECM）对细胞功能发挥着重要作用，在胚胎发育、伤口愈合、癌症转移和炎症等多种不同过程中起着至关重要的作用。细胞与基质之间的相互作用由多种针对ECM不同成分的细胞表面受体介导。基质受体的整合素家族是迄今为止研究最为深入的一组，已被证明在其他系统的细胞-基质和细胞-细胞相互作用中发挥重要作用。最近，已明确了肾小球及培养的肾小球细胞中存在的整合素受体类型，并推测了它们在肾小球损伤中的潜在作用。本综述将总结关于整合素受体的现有知识、它们在肾脏中的分布、可能在调节肾小球细胞对损伤反应中起作用的培养肾小球细胞-基质相互作用，以及整合素和其他肾小球细胞基质受体作为蛋白尿性病变中损伤靶点的潜在作用。
